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Microbial problems in care products and the mechanism of action of preservatives


Microorganisms commonly found in contaminated cosmetics include bacteria, molds and yeasts, of which bacteria are dominant. The more common polluting bacteria are Gram-positive bacteria such as Staphylococcus aureus, spore, streptococcus and Clostridium, and Gram-negative bacteria such as Pseudomonas, Salmonella and Vibrio. The most common source of contamination for toiletries, such as shower gels and shampoos, is Gram-negative bacteria, of which Pseudomonas (aeruginosa and Burkholderia cepacia) are The most frequently isolated contaminating microorganisms, followed by Enterobacteriaceae, are also commonly found in such contaminated products.

 

The effect of preservatives on microorganisms is that they can selectively act on a certain part of the metabolism of microorganisms, so that their growth is inhibited or killed, but it is harmless to human cells, thus achieving a relatively safe product antiseptic effect. Its mechanism of action mainly has the following three aspects:

 

1.  1. Denature or coagulate microbial proteins

The preservative acts on the enzyme or protein in the cell after it has passed through the cell membrane, interferes with the synthesis of the protein or denatures it, and causes the cell to die. For example, boric acid, benzoic acid, sorbic acid, etc. act on cells to denature proteins, and alcohols and aldehydes tend to coagulate and precipitate proteins, thus having an antibacterial effect.

 

2.  2. Inhibit the formation of microbial cell walls

Micropreservatives can hinder the synthesis of substances that form cell walls, such as cationic surfactants, which inhibit the synthesis of peptidoglycan, an important component of the cell wall, and some can inhibit the synthesis of ubiquitin in the cell wall. Preservatives can disrupt the structure of the cell wall, causing the cell to rupture or lose its protective effect, thereby inhibiting microbial growth and causing death.

 

3. Functional cell membranes that damage the cell membrane can cause cellular suffocation and metabolic disorders. The damaged cell membrane causes leakage of cellular material and causes microbial death. For example, benzoic acid, benzyl alcohol, salicylic acid, etc., they damage the protein structure of normal cells, and cause cells to die.

 

Our company's 3Q-401 daily chemical tank preservative, this product is a broad-spectrum bactericidal preservative, which can be widely used in daily-use lotion industry to wash away cosmetics (such as: detergent, hand soap, shower gel, wash) Sterilization and antiseptic of water, decontamination, etc.) It has good compatibility with various ingredients in cosmetics, and its antibacterial effect is not affected by surfactants, proteins and other ingredients. Excellent control of bacteria, mold and yeast in the concentration range.

 

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Contact: Mr.guan

Phone: +86-18641134053

Tel: +86-411-82384176

Email: twhx@tianweichemical.com

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