Comparison of commonly used preservatives in in vitro diagnostic reagents

02-09-2021

    The stability of in vitro diagnostic reagents is the key to restricting the marketization of products. There have been a number of patents on preservatives for in vitro diagnostic reagents abroad, but the domestic is still in the exploration stage. With the continuous development of in vitro diagnostic reagents, the requirements for preservatives will become higher and higher, and preservatives that are highly toxic to the human body and the environment, such as thimerosal and sodium azide, will gradually be replaced. In the future, preservatives will develop in the direction of broad spectrum, high efficiency, low toxicity and environmental protection.


preservative

Principle of action

advantageshortcoming
Sodium AzideInhibit enzyme activityThe effect is remarkableVery toxic, inhibits a variety of enzymes
ThimerosalInhibit enzyme activityBroad spectrum, strong antibacterial powerPotentially harmful
GentamicinBinding to ribosomesBroad antibacterial spectrumProne to drug resistance
IsothiazolinonesInhibit enzyme activityEfficient and stableHave a certain irritation and sensitization


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